This article provides an updated picture of the ESC Working Group on Cardiovascular Pharmacotherapy. Created in the 1980s, the ESC WG-CVP cover the whole spectrum of cardiovascular disease, and is actively involved in all aspects of cardiovascular pharmacology and pharmacotherapy, in a truly translational horizon: from basic to clinical pharmacology, form basic research to clinical trials. With over 550 members (27% women, 73% men) from different countries worldwide, the WG-CVP promotes and helps disseminate the most recent advances in pharmacotherapy, supports research dealing with precision dosing and personalized treatments, and produces educational programmes that contribute to the professional development of physicians.