The recently published article by Domagala et al in Cells is a very interesting and welcome review about cellular, molecular and clinical aspect about aortic aneurysm. Authors review epidemiological aspects of aortic aneurysm with special interest in abdominal aneurysm which are more prevalent . With very representative figures the manuscript revise anatomical structure of aortic aneurysm, reviewing structural aspects of its development from physiology to pathophysiology and analyzing also molecular factors involved in pathogenesis of abdominal aortic aneurysm which are collected in a summary table. Of course, genetic aspects are also considered. Inflammation is the most common pathological factor which must be take into account as a therapeutic target. An early diagnosis and a holistic approach are essential for the correct management of this pathology.
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