Chronic Ischemic Cardiovascular Disease (CICD) Registry

Coronary Artery Disease (CAD)

CAD is the first cause of mortality worldwide today and continues to be a major burden on public health1.

Despite falling CAD mortality rates in Western European countries, the number of CAD patients may actually be increasing, with ageing populations and the improving prognosis of coronary patients due to more effective treatments 2.

CAD by itself is the single most common cause of death in Europe, accounting for over 1.92 million deaths each year. This is true at all ages, including deaths before the age of 65 (figure provided by the University of Oxford).

Interregional differences are even more evident for CAD risk factors: smoking, dietary patterns, levels of physical activity, obesity and diabetes, arterial hypertension and dyslipidemia. The West to East gradient of both CAD prevalence and mortality is associated with the same gradient for the prevalence of risk factors for atherosclerosis. Both are inversely related with both pro capite and national gross product of the European countries.

Cerebrovascular Disease

In the Western world, ischemic stroke has a major public health impact as the first cause of long-term disability and the third leading cause of death. Stroke mortality ranges from 10% to 30%, and survivors remain at risk of recurrent neurological and cardiac ischemic events.

Objectives and characteristics of the study

This registry is being undertaken to improve knowledge about the care of patients with CAD and/or PAD. The registry will provide important data on: 

• Demographic characteristics
• Clinical profiles
• Management and diagnostic-therapeutic processes according to the clinical profiles as well as identifying gaps (and possibly their causes) between current routine treatment and evidence-based treatment recommended by ESC guidelines.
• To determine short- and long-term outcomes and their determinants in this population of patients.

This is an international, prospective, observational, longitudinal registry in patients with CICD with a yearly patient follow-up over three years.

The study is approved by local institutional review boards and all patients will give informed consent in accordance with national and local guidelines.

Enrolment of patients in this study will end mid-2018. If you would like to join, please contact your National Cardiac Society.

Patient Population

All consecutive patients with CICD either scheduled for an elective revascularisation procedure or visited on an ambulatory basis by participating centres.

No data will be collected before the detailed information is given to the patient and a signed informed consent is obtained.

Publications

Please see our Publications page for the main publication on the Pilot registry.

Study Organisation

The Executive Committee of the registry is chaired by Michel Komajda.

The 56 ESC member countries have been invited to join this phase of the registry. If you are interested in joining, please contact your national cardiac society.

The Executive Committee

Michel Komajda (Chairman)
Mathieu Kerneis (Research Fellow)
Luigi Tavazzi
Aldo Maggioni, EORP Scientific Coordinator, ex officio (non-voting)
Gabriel Steg
Marco Valgimigli
Roberto Ferrari
Francesco Cosentino

The Steering Committee

The Steering Committee is composed of one National Coordinator per participating country. National Societies are responsible for national coordinators and selection of participating centres. To date, the members are as follows:

Artan Goda (AL)
Volha Sujayeva (BY)
Assoc. Prof. Arman Postadjian (BG)
El Etriby (EG)
Peep Laanmets (EE)
Harald Rittger (DE)
Vakhtang Chumburidze (GE)
Constantinos Tsioufis (GR)
Robert Klempfner (IL)
David Rott (IL)
Zoran Olivari (IT) (coordination of cath labs of cardiology departments)
Francesco Fedele (IT) (coordination of clinics of general hospitals without interventional facilities)
Gani Bajraktari (KV)
Erkin Mirrakhimov (KG)
Iveta Mintale (LV)
Rimvydas Slapikas (LT)
Hanna Szwed (PL)
Pedro Braga (PT)
Dragos Vinereanu (RO)
Ana Djordjevic Dikic (RS)
Yuri Lopatin (RU)
Luis Rodríguez Padial (SP)
Mohammed Sami Mourali (TN)

The Pilot Registry Committees

The Executive Committee

Michel Komajda (Co-Chairman)
Franz Weidinger (Co-Chairman)
Luigi Tavazzi
Aldo Maggioni (EORP)
Gabriel Steg
Marco Valgimigli
Alberto Cremonesi
Serge Kownator
Roberto Ferrari
Francesco Cosentino
Mathieu Kerneis (Research Fellow)

The Steering Committee

The Steering Committee is composed of one National Coordinator per participating country. National Societies are responsible for national coordinators and selection of participating centres.

Éric van Belle (FR)
Harald Rittger (DE)
Constantinos Tsioufis (FR)
Zoran Olivari (clinics with cath labs) (IT)
Francesco Fedele (clinics without interventional facilities) (IT)
Iveta Mintale (LV)
Rimvydas Slapikas (LT)
Hanna Szwed (PL)
Miguel Mendes (PT)
E.V. Shlyakhto (RU)

References

1. Leal J, Luengo-Fernandez R, Gray A, Petersen S, Rayner M. Economic burden of cardiovascular diseases in the enlarged European Union. European heart journal. Jul 2006;27(13):1610-1619.
2. Tunstall-Pedoe H, Kuulasmaa K, Mahonen M, Tolonen H, Ruokokoski E, Amouyel P. Contribution of trends in survival and coronary-event rates to changes in coronary heart disease mortality: 10-year results from 37 WHO MONICA project populations. Monitoring trends and determinants in cardiovascular disease. Lancet. May 8 1999;353(9164):1547-1557
3. Steg PG, Bhatt DL, Wilson PW, D'Agostino R, Sr., Ohman EM, Rother J, Liau CS, Hirsch AT, Mas JL, Ikeda Y, Pencina MJ, Goto S. One-year cardiovascular event rates in outpatients with atherothrombosis. Jama. Mar 21 2007;297(11):1197-1206.
4. Tendera M, Aboyans V, Bartelink ML, Baumgartner I, Clement D, Collet JP, Cremonesi A, De Carlo M, Erbel R, Fowkes FG, Heras M, Kownator S, Minar E, Ostergren J, Poldermans D, Riambau V, Roffi M, Rother J, Sievert H, van Sambeek M, Zeller T, Bax J, Auricchio A, Baumgartner H, Ceconi C, Dean V, Deaton C, Fagard R, Funck-Brentano C, Hasdai D, Hoes A, Knuuti J, Kolh P, McDonagh T, Moulin C, Poldermans D, Popescu B, Reiner Z, Sechtem U, Sirnes PA, Torbicki A, Vahanian A, Windecker S, Kolh P, Torbicki A, Agewall S, Blinc A, Bulvas M, Cosentino F, De Backer T, Gottsater A, Gulba D, Guzik TJ, Jonsson B, Kesmarky G, Kitsiou A, Kuczmik W, Larsen ML, Madaric J, Mas JL, McMurray JJ, Micari A, Mosseri M, Muller C, Naylor R, Norrving B, Oto O, Pasierski T, Plouin PF, Ribichini F, Ricco JB, Ruilope L, Schmid JP, Schwehr U, Sol BG, Sprynger M, Tiefenbacher C, Tsioufis C, Van Damme H. ESC Guidelines on the diagnosis and treatment of peripheral artery diseases: Document covering atherosclerotic disease of extracranial carotid and vertebral, mesenteric, renal, upper and lower extremity arteries: the Task Force on the Diagnosis and Treatment of Peripheral Artery Diseases of the European Society of Cardiology (ESC). European heart journal. Nov;32(22):2851-2906.

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