Why, when and how should we perform a genetic counseling? Those important aspects are discussed in this interview where Pr Antoine Bondue (Cardiovascular Genomics council, Brussels) meets Pr Eloisa Arbrustini (San Matteo Hospital, Pavia, Italy), Mrs Stephanie Oates (genetic counselor at Great Ormond Street Hospital, London, UK) and Mrs Ruth Biller (patient organization representative, Germany). This content highlights the definition of genetic counseling (2 min 5sec); the practical organization of genetic counseling (6 min 10 sec); the impact for patient and relatives (13 min 15 sec); variant classification (18 min 45 sec); incidental finding (28 min 35 sec); genetic counseling in children (29 min 40 sec); genetic testing in the absence of a definitive clinical diagnosis like in unexplained SCD (41 min 44 sec).