In this interview with Professor Martine Gilard (Hospital Cavale Blanche, Brest, France), joins Dr Riccardo Asteggiano (LARC [Laboratorio Analisi Ricerca Clinica], Turin, Italy) to discuss the long-term follow-up of patients with acute coronary syndrome. The main aspects of secondary prevention and of clinical control are debated and a clear indication of the follow-up of these complex patients in General Cardiology are given’.